Bi-Axial

Rotating

Bioreactor

TisXell Bi-Axial Rotating System distinctive design offers a nurturing culture environment to cells and tissues. Its unique bi-directional revolution simulates nature’s biological ecosphere, accelerating homogenous cell growth throughout 3D tissue constructs.

Benefits from using the TisXell Bi-Axial Bioreactor

Accelerates cell growth, differentiation and cell proliferation, mimicking native extracellular matrix (ECM)
Supports homogenous cell culture at the surface and core of 3D scaffolds
Maintains functionality and viability of tissue constructs
Reduces formation of necrotic neo-tissue that interferes with subsequent implantation process
Promotes integration of implants with surrounding tissue and supports the structural integrity in regeneration of tissues and organs

Fig 1. Up to 10x cells expansion achievable! Extension of two days in growth proliferation was seen from Rotating chamber as compared to Static chamber in cell lines we have tested on. Results may differ from the manipulation of cell seeding population with fixed volume of media and chamber size.

Fig 2. TisXell (blue) has shown an increased in cell proliferation as compared to other culture systems

Cells retain native markers

The levels of Col 2 and Agg were found to be much higher in the biaxial rotary environment. Clearly indicating that cells grown under biaxial rotary condition retain their native chondrogeneic markers better compared to static condition.