The cellZscopeE is the ideal entry-level system for computer-controlled TER (transepithelial / -endothelial resistance) measurements. TER of the cell layers under investigation is determined in real-time. Reliable long term measurements over days and weeks can be carried out.
The convincing performance and instrument operations and easy maintenance make the cellZscopeE the ideal tool for controlling the confluence of cell layers as well as for studying the influence of substances on the barrier function. It sweeps over a wide frequency range instead of simply measuring at a very few frequency points. This ensures a reliable and unambiguous detection of cell layer properties.
The innovative design of the cellZscopeE provides investigators full apical and basolateral access to all wells. Even without the user has to fully open the cell module. An aperture in the cover gives access to the inner and outer compartment of each well. Medium can easily be exchanged and substances added with a pipette.
Single-piece stainless steel “pots” serve as bottom electrodes, as vessels for holding the cell culture medium, and as supports for cell culture inserts.
The lid is made of highest quality stainless steel not only providing superior durability but also excellent compatibility with all standard cleaning and sterilization methods. The bottom electrodes can be detached easily without the use of tools. These features make the cellZscope systems a snap to clean and sterilize.
Three well sizes are available for use with small (“24-well” type), mid-sized (“12-well” type), or large (“6-well” type) inserts, respectively.
Different sizes of cell culture inserts can be combined within a single Cell Module. Thus allowing the automated monitoring and direct comparison of the barrier properties of cell layers housed in up to three different sized cell culture inserts.
The cellZscopeE is compatible with a variety of standard cell culture inserts from different manufacturers. Three versions of the electrodes are available. They are tailored for use with small (“24-well” type), mid-sized (“12-well” type), or large (“6-well” type) inserts, respectively. Different well sizes can be combined within one Cell Module.