The cellZscope+ is computer-controlled and allows automated fast process monitoring as well as reliable long term measurements over days and weeks. The ohmic resistance (TER, transepithelial / -endothelial resistance) and capacitance (Ccl) of the cell layers under investigation are determined in real-time.
The convincing performance and instrument operations and easy maintenance make the cellZscope+ the ideal tool for controlling cellular barriers. It sweeps over a wide frequency range instead of simply measuring at a very few frequency points. This ensures a reliable and unambiguous detection of cell layer properties.
The cellZscope+ is designed to ensure simple operation and maximum flexibility. Its Cell Module provides investigators full apical and basolateral access to all wells and is easily transferable to a laminar flow hood.
Single-piece stainless steel “pots” serve as bottom electrodes, as vessels for holding the cell culture medium, and as supports for cell culture inserts.
A magnetic mount makes handling of the upper electrodes comfortable and accurate positioning is guaranteed. Top and bottom electrodes can be detached easily without the use of tools. These features make the cellZscope systems a snap to clean and sterilize.
Three well sizes are available for use with small (“24-well” type), mid-sized (“12-well” type), or large (“6-well” type) inserts, respectively.
Different sizes of cell culture inserts can be combined within a single Cell Module. Thus allowing the automated monitoring and direct comparison of the barrier properties of cell layers housed in up to three different sized cell culture inserts.
The cellZscope+ is compatible with a variety of standard cell culture inserts from different manufacturers. Three versions of the electrodes are available. They are tailored for use with small (“24-well” type), mid-sized (“12-well” type), or large (“6-well” type) inserts, respectively. Different well sizes can be combined within one Cell Module.